Depends on what you want to do with it. In stock form the ST215 motor is a bit fragile due to the higher compression, however the block is stronger, at least in the area around the water pump, not sure about the area between cylinder 2 & 3 when some earlier 3S-GTEs have show a tendency to cracking, possibly due to thin cylinder walls, which is exacerbated by core shift during casting. I should be able to answer this when I get around to sectioning FarmerDave's old block.
As to aftermarket parts supply, apart from the intake cam, which needs modification to accept the position trigger, all parts for the Gen III should be the same.
IMO, with the exception of the one piece turbo manifold, the stock ST215 parts are better designed, and probably have greater potential than the same Gen III items.
The only real issue is the ECU, but I assume that it would be replaced. There are some aftermarket plug and play solutions, but IMO they don't provide a sensible solution as most are no user programmable. Although it's not necessarily relevant to an engine transplant situation, I've recently found a source for a patch harness so it's a simple matter of making any ECU plug and play, and depending on the ECU could even be used as a piggyback to allow the stock ECU to run the auto transmission
Another thing to consider is that there is a better supply of Caldina engines, at least ex-Japan there is, and there isn't the demand for them as the USA is still locked into the Gen III swap mentality, so you pay a premium for them.